|
KMID : 0379520060220040439
|
|
한국독성학회지
2006 Volume.22 No. 4 p.439 ~ p.443
|
|
|
Single Oval Dose Toxicity Study of the Extract of Aralia elata in Mice
|
|
Yang Hee-Kyoung
Jin Ju-Yeon
Kim Ji-Min
Ko Mun-Su
Hong Hyun-Ju
Kim Sang-Chul
Lee Young-Jae
|
|
|
Abstract
|
|
|
|
This study was conducted to investigate the potential acute toxicity of Aralia elata by a single oral dose in ICR mice. Thirty mice of each sex were randomly assigned to three groups of 10 mice each. The test articles were administered once by the gavage to mice at dose levels of 0, 2,500 and 5,000 mg/kg body weight. The mortality and changes on body weight and clinical signs of gross observation were monitored for 14 days after dosing. At the end of 14-day observation period, all animals were sacrificed and complete gross postmortem examinations were performed. There were no dead animal and adverse effects on clinical signs, the body weight and the gross finding. As the results, we could not find any toxic effect at the dose levels of 2,500 or 5,000 mg/kg in mice and the minimal lethal dose was considered to be over 5,000 mg/kg body weight in mice.
|
|
|
KEYWORD
|
|
|
Aralia elata, Acute oral toxicity, Mice
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|